Chronic Recurrent Multifocal Osteomyelitis
(CRMO)
Chronic Recurrent Multifocal Osteomyelitis (CRMO) is
a rare disease occurring in childhood. It is characterized
by insidious onset and variable clinical manifestations
that may mimic infections or malignancies [1]. Since
CRMO may be neither multifocal nor recurrent, some
authors suggest replacing it with the term chronic
nonbacterial osteomyelitis (CNO) that includes different
disorders with sterile bone inflammation [2]. Synovitis,
acne, pustulosis, hyperostosis and osteitis syndrome
(SAPHO) is the adult form of CRMO with prominent skin
manifestations [3]. CRMO is frequently associated with
other inflammatory diseases such as psoriasis and
inflammatory bowel disease [4]. CRMO pathogenesis is
largely unknown; however, an unbalance towards
proinflammatory cytokines has been demonstrated [5,6].
Recently a South Asian child with CRMO and psoriasis has
been found harboring an autosomal recessive mutation of
FBLIM1 gene [7].
Look here for full article: 👉👉 https://medwinpublishers.com/JOBD/JOBD16000185.pdf
